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How to get from Safed to Tel Aviv by public transportation?

The best way would be by bus.
Egged bus no. 846 - will take you from Safed central bus station to TA central bus station.
It also has 3 more stations in TA - all the way through the north of the city.
on weekdays it leaves Safed at 5:20 am and 8:15 am, Fridays only at 8:15***.
It takes 3.5 hours and costs 45 NIS.

There's also the option of taking a train from akko to Tel aviv, and get to Akko by a bus.
From Safed to Akko train station there are buses no. 361 and 501
Both lines take 1:30 hours and cost 30.5 NIS

The train to akko leaves tel aviv central train station every hour and 22 minutes, and tak

Search For train time and cost here:

All bus details – on Egged website in English. 
* For line 361 details in hebrew click here.
** For line 501 details in hebrew Click here.
*** For Line 846 details in Hebrew click here.

If you wish to check on specific times and rates, you may do so in the following means:

Israel Train Tel: *5770
Egged Tel: *2800 Text message: 2800
Superbus (Beit Shemesh, Ramla, Modi'in) Tel: 1-700-700-181
Kavim (Petach Tikva, Afula) Tel: *82254
Dan (Gush Dan) Tel: *3456 Also operate info. center at Tel Aviv central bus station

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